The Vandalia Leader-Union says, 11 adult males were in the church van when it rolled over. Five of the passengers died in the crash.
Fayette County Coroner Bruce Bowen says five of the passengers were pronounced dead at the scene. The accident occurred just before 9:45 Monday morning, near mile marker 57 on Interstate 70.
According to the Illinois State Police, the 2002 Dodge van left the roadway, which resulted in several occupants of the vehicle to be ejected.
A spokeswoman for Fayette County Hospital said they received four patients. Two other accident victims were taken to Greenville Regional Hospital.
The van was returning to Maryland from a church gathering in California.
No other injuries have been reported.